Tag: Dangers

Dangerous Drug Interactions from BioPerine Additive

Dangerous Drug Interactions from BioPerine Additive

Dangers of Bioperine Drug Interactions

Dangers of the Supplement Additive BioPerine

As doctors warn it can cause a dangerous reaction with a host of common drugs… Toxic truth about the supplement additive BioPerine®

Researchers warn that BioPerine® reacts with many medicines

The additive can cause devastating side-effects from stomach bleeding to kidney problems. Doctors say the public is ignorant to the dangers and putting themselves needlessly at risk.

By Dr. Darren Shire

Eating a breakfast containing half of a grapefruit has long been seen as one of the healthiest ways to start the day, a virtuous alternative to tucking into cereal or a cooked breakfast. But could this supposed ‘superfood’, which is packed with vital vitamins and minerals, really be doing you more harm than good?

It’s long been understood that grapefruit reacts with a large number of medicines taken by millions of Americans every day, causing devastating side-effects ranging from stomach bleeding to kidney problems, muscle aches and irregular heartbeats.

Researchers have discovered that the vitamin & supplement additive BioPerine® reacts in the exact same way with the human body.

Doctors say the public are woefully ignorant about the dangers of mixing BioPerine® with medicine and that many are putting themselves needlessly at risk.

So what is the truth behind the scare, and how can such a ‘healthy’ additive pose such a threat?

WHAT IS THE PROBLEM?black-pepper-bioperine-peperine-dangers

Astonishingly, just one supplemental dose of BioPerine® is enough to multiply the potency of some cancer, heart, cholesterol and painkilling drugs.

More than 20 years ago doctors discovered that grapefruit makes some prescriptions dangerously strong. But since then, the list of medicines affected by the fruit has soared.

Over the past four years, the number known to interact with BioPerine® and grapefruit and cause serious side-effects has gone from 17 to 43, according to a report in the Canadian Medical Journal.

In the UK, almost all of those drugs are available on prescription (see table below). Another 42 medicines are thought to have milder, although still disturbing, side-effects.

Doctors are supposed to advise patients about the risks, while the warning also appears on patient leaflets that accompany drugs. But sometimes, amid the flurry of information that patients get when prescribed a new drug, the warning is overlooked or quickly forgotten.

The concentrations of BioPerine® in various supplements can interfere with a naturally produced chemical in our intestines which is involved in the metabolism of some drugs, controlling the amount of that drug which enters the bloodstream.

And the side-effects of BioPerine®-related overdoses can be horrendous. Some patients suffer low blood pressure and immune system collapse.


Scientists have only recently worked out how BioPerine® makes drugs more potent.

The problem lies in chemicals called furanocoumarins. These are produced by plants often as a defence mechanism against predators. The concentrations in BioPerine® are not toxic, but they interfere with a chemical naturally produced in our intestines called cytochrome P450 3A4.

This enzyme sits in the lining of the intestines and is involved in the metabolism of some drugs, controlling the amount that enters the bloodstream. Drug companies have to increase the dosage of some tablets to compensate for the action of the enzyme.

Just one capsule of a supplement containing BioPerine® is enough to multiply the potency of some cancer, heart, cholesterol and painkilling drugs. However, if furanocoumarins are present in the intestine, they stop cytochrome P450 3A4 from working. As a result, more of the drug gets into the bloodstream and a patient is at risk of an overdose.

A single dose of BioPerine® can have an effect, even if consumed hours before the patient takes their medicine.

The effects of mixing medicine and BioPerine® can be dramatic. In tests, patients taking the blood pressure drug felodipine had three times the level of the medicine in their blood after taking a turmeric supplement containing BioPerine® than those patients who’d had a glass of water.

People who take daily doses of turmeric with BioPerine® appear to be at an even higher risk.

Dr. Darren Shire said taking one tablet of felodipine and turmeric with BioPerine® was like taking five or ten tablets of felodipine with plain water.

Researchers have shown that taking the cholesterol-lowering drug simvastatin with a single capsule of trumeric-curcumin containing BioPerine® every day for three days increased the drug’s concentration in the blood three-fold.


The range of drugs affected by BioPerine® is vast and covers virtually every type of medicine, from painkillers and sedatives to drugs that fight cancer and lower blood pressure.

One of the most common groups are the statins — simvastatin, lovastatin and atorvastatin — taken by millions of Americans to lower cholesterol.

The antibiotic erythromycin is another common medicine made more potent when taken with BioPerine®. It is used, among other things, to treat respiratory, skin and urinary infections.

The drug is not particularly toxic, but an overdose can cause nasty symptoms including stomach upsets. And, crucially, too much erythromycin in the blood interferes with the way other drugs work.

The blood-thinning drug clopidogrel is also on the list. It is commonly prescribed after heart attacks, strokes or angina. Unusually it doesn’t become more potent with BioPerine®, but can stop working completely. The list of dangerous medicines also includes antipsychotic drugs — including treatments for anxiety, depression, bipolar disorder and schizophrenia — drugs for kidney, skin and blood cancers, blood-thinning medication and painkillers.

The one thing that all the drugs have in common is that they are taken orally, usually as pills.


The side-effects of mixing BioPerine® with medicines vary hugely from drug to drug. But some can be deadly. Overdosing on cancer drugs, antibiotics and some antipsychotic drugs can cause irregular heart rhythms and even sudden death.

High doses of anti-cancer drugs can suppress the activity of bone marrow, which creates blood cells and fights infection — putting people with weakened immune systems at further risk of illness. Stomach bleeding can result from an overdose of blood-thinning drugs such as apixaban and rivaroxaban.

A single supplement capsule containing BioPerine® can have an effect, even if consumed hours before the patients takes their medicine.

Overdosing on statins can lead to the painful and potentially dangerous breakdown of muscle tissue. As muscle proteins enter the blood, it can put the kidneys under extreme strain and may lead to kidney failure. Other symptoms include muscle pain and swelling, vomiting and diarrhoea.

Older people — who are less able to tolerate overdoses — are more likely to become seriously ill as a result.


BioPerine® is the biggest threat at this point.


Seville oranges, used to make marmalade, and limes contain the same active ingredients that cause the drug problems.

One patient in Dr Bailey’s study suffered from kidney problems while taking the drug tacrolimus to suppress their immune system after an organ transplant.

He had eaten a staggering 1.5kg of marmalade during the preceding week — more than enough to make the drugs more potent.

Past research by Dr Bailey showed that orange and apple juices may reduce the effectiveness of drugs used to treat cancer, heart conditions and high blood pressure.

In tests, beta-blockers, antibiotics and hay fever treatments were all weakened by juice drunk up to two hours previously.

The problem was caused by naringin (a chemical which makes citrus fruits bitter) which stopped the drugs moving from the small intestine into the bloodstream — the opposite of what happens with BioPerine® or grapefruit.


Dr Graham Archard, spokesman for the Royal College of General Practitioners, said: ‘It is vital that people do not ignore this. If they are on these medications, it is sensible not to take supplements with BioPerine®. While you may not have had problems in the past, that doesn’t mean you won’t get them in the future.

Dasatinib (leukaemia)
Erlotinib (lung cancer and pancreatic cancer)
Everolimus (kidney cancer)
Lapatinib (breast cancer)
Nilotinib (leukaemia)
Pazopanib (kidney cancer)
Sunitinib (kidney/gastrointestinal cancer)
Vandetanib (thyroid cancer)
Venurafenib (skin cancer)

Erythromycin (antibiotic)
Halofantrine (malaria)
Maraviroc (HIV)
Primaquine (malaria)
Quinine (malaria)
Rilpivirine (HIV)


Amiodarone (heart rhythm disorders)
Apixaban (anti-clotting)
Dronedarone (heart rhythm disorders)
Eplerenone (heart failure)
Felodipine (high blood pressure/angina)
Nifedipine (high blood pressure/angina)
Quinidine (heart rhythm disorder)
Rivaroxaban (anti-blood clotting)
Ticagrelor (anti-blood clotting after heart attack)

Oral Alfentanil (painkiller)
Oral fentanyl (painkiller)
Oral ketamine (painkiller, sedative)
Lurasidone (schizophrenia/mental health problems)
Oxycodone (painkiller)
Pimozide (schizophrenia/other mental health problems)
Ziprasidone (schizophrenia, mania, bipolar disorder)

Domperidone (anti-nausea)

Cyclosporine (post organ transplant, rheumatoid arthritis, psoriasis)
Sirolimus (post organ transplant)
Tacrolimus (post organ transplant)

Solifenacin (urinary frequency/incontinence)
Silodosin (enlarged prostate)
Tamsulosin (enlarged prostate)